max in WT synaptoneurosomes, suggesting that Src signaling may very well be downregulated in KI synapses. On the flip side, our capacity to rescue SERT perform in KI midbrain synaptoneurosomes from the inhibition of FAK suggests elevated FAK signaling downstream in the Pro32Pro33 mutant, as confirmed by amplified pFAK localization in 5-HT synapses.